000			01993cam a2200229 a 4500
001			17505371
005			20170922102222.0
008			121019s2013 ctua b 001 0 eng
020			_a9781443412131
040			_cPK-LaUMT
082	0	0	_a579.29 _223 _bING-F
100	1		_aIngram, Jay
245	1	0	_aFatal flaws : _bhow a misfolded protein baffled scientists and changed the way we look at the brain / _cJay Ingram
260			_aToronto : _bHarper PerennialPress, _c2013
300			_a260 p. : _bill. ; _c22 cm.
520			_a"Discovered and identified as the cause of mad cow disease only three decades ago, the prion is a protein molecule that, when misshapen in the brain, becomes fatal. Novel and controversial, prions have provoked a scientific revolution. They challenge the very foundations of biology: A disease-causing entity with no genetic material at all? A molecule capable of infecting, multiplying, and killing? This book recounts the birth of prion science and the imaginative detective work scientists have undertaken as they struggle to find the answers to devastating brain diseases from mad cow and Creutzfeld-Jakob disease to Parkinson's, Alzheimer's, Lou Gehrig's, and others. As in each of his best-selling books, Jay Ingram here makes complex scientific concepts accessible and shows how little-known events may have profound significance. He describes the development of prion science as a rough-and-tumble affair, with rivals, eccentrics, interfering governments, and brilliantly creative people all playing salient roles. Weaving biology, medicine, human tragedy, discovery, and bitter scientific competition into his account, he reveals the stunning potential of prion science, whose discoveries may unlock the answers to some of humankind's most destructive diseases"--Provided by publisher.
650	1	2	_aPrion Diseases _xphysiopathology.
650	2	2	_aPrion Diseases _xhistory.
650	2	2	_aPrions _xhistory.
650	2	2	_aPrions _xpathogenicity.
942			_cBK
999			_c98398 _d98398